Towards patient-specific modeling of cardiovascular diseases

Cardiovascular diseases (CVD) are the leading cause of death globally. More in-depth understanding of the pathophysiology of the disease and patient-specific risk assessment are critically important in reducing CVD-related mortality. Research in Seungik Baek’s Cardiovascular and Tissue Mechanics Laboratory involves the computational modeling of growth and remodeling of vascular tissues and characterizing material behavior of biological soft tissues and mechano-sensitive cellular behavior. Dr. Baek’s research integrates medical imaging data from patients with computational methods to help doctors with the clinical management and surgical treatment of vascular diseases. The computational model of vascular growth and remodeling is implemented on a geometry constructed from medical images and patient specific data. A new computational framework is being used to account for coupling between hemodynamic loads on the vessel wall and evolution of arterial geometry and its material properties during the progression of the life threatening diseases, such as abdominal aortic aneurysms and pulmonary hypertension.