Date
Event Location
3540 Engineering

Mechanical Engineering Seminar

Tuesday, October 29, 2019

3:00 p.m., 3540 Engineering Building

Refreshments Served at 2:45 p.m.

 

Hidden Topological Structures and Biotransport Processes in Cardiovascular Fluid Mechanics

 

Dr. Amirhossein Arzani  

Cardiovascular Biomechanics Lab

Mechanical Engineering Department

Northern Arizona University

 

Abstract: 

 

Cardiovascular disease is the leading cause of death in the US. Complex anatomies and the pulsatile nature of blood flow in large diseased arteries often lead to chaotic flow with complicated wall shear stress (WSS) patterns. Lagrangian coherent structures (LCS) have been used to study the flow physics (vortex structures, mixing, etc.) in cardiovascular flows. However, a close connection between LCS and cardiovascular disease is difficult to establish. Cardiovascular disease typically localizes at the vessel wall. In this talk, I demonstrate how WSS could be used to study the connection between the fluid mechanics of blood flow and the biology of cardiovascular disease. I first review the concept of LCS, which is traditionally applied to velocity data. Next, I introduce the new concept of Lagrangian wall shear stress structures (WSS LCS) and demonstrate how they could be used to study near-wall transport patterns in different cardiovascular complications. Namely, I show how WSS LCS predicts biochemical surface concentration patterns obtained from 3D convective mass transport models in aneurysms and coronary artery disease. I also discuss how these hidden structures could be applied to other fluid flow systems (e.g. heat transfer enhancement).  Finally, I present a two-way coupled coronary artery plaque growth model where information gained from WSS could be used to model fluid flow driven disease growth.

 

Bio: 

 

Dr. Amirhossein (Amir) Arzani is an Assistant Professor at Northern Arizona University’s Mechanical Engineering Department.  He obtained his MS and PhD degrees in Mechanical Engineering from Illinois Institute of Technology and UC Berkeley, respectively. His Cardiovascular Biomechanics Lab develops new multiphysics and multiscale computational models to study cardiovascular disease growth. His group is also interested in studying flow physics and transport in complex systems.

 

Persons with disabilities have the right to request and receive reasonable accommodation. Please call the Department of Mechanical Engineering at 517-355-5131 at least one day prior to the seminar; requests received after this date will be met when possible.